Brassinosteroids and analogs as neuroprotectors: Synthesis and structure-activity relationships
Identifieur interne : 001548 ( Main/Exploration ); précédent : 001547; suivant : 001549Brassinosteroids and analogs as neuroprotectors: Synthesis and structure-activity relationships
Auteurs : Jihane Ismaili [Canada] ; Martin Boisvert [Canada] ; Fanny Longpre [Canada] ; Julie Carange [Canada] ; Céline Le Gall [Canada] ; Maria-Grazia Martinoli [Canada] ; Benoit Daoust [Canada]Source :
- Steroids [ 0039-128X ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
We have demonstrated previously that the brassinosteroid (BR) 24-epibrassinolide exerts neuroprotective effects deriving from its antioxidative properties. In this study, we synthesized 2 natural BRs and 5 synthetic analogs and analyzed their neuroprotective actions in neuronal PC12 cells, against 1-methyl-4-phenylpyridinium (MPP+), a neurotoxin known to induce oxidative stress and degenerescence of dopaminergic neurons characteristic of Parkinsonian brains. We also tested the neuroprotective potential of 2 commercially available BRs. Our results disclosed that 6 of the 9 BRs and analogs tested protected neuronal PC12 cells against MPP+ toxicity. In addition, our structure-activity study suggests that the steroid B-ring and lateral chain play an important role for their neuroprotective action.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000222
- to stream PascalFrancis, to step Curation: 000A30
- to stream PascalFrancis, to step Checkpoint: 000191
- to stream Main, to step Merge: 001605
- to stream Main, to step Curation: 001548
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Brassinosteroids and analogs as neuroprotectors: Synthesis and structure-activity relationships</title><author><name sortKey="Ismaili, Jihane" sort="Ismaili, Jihane" uniqKey="Ismaili J" first="Jihane" last="Ismaili">Jihane Ismaili</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Boisvert, Martin" sort="Boisvert, Martin" uniqKey="Boisvert M" first="Martin" last="Boisvert">Martin Boisvert</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Longpre, Fanny" sort="Longpre, Fanny" uniqKey="Longpre F" first="Fanny" last="Longpre">Fanny Longpre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Le Gall, Celine" sort="Le Gall, Celine" uniqKey="Le Gall C" first="Céline" last="Le Gall">Céline Le Gall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Daoust, Benoit" sort="Daoust, Benoit" uniqKey="Daoust B" first="Benoit" last="Daoust">Benoit Daoust</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0109702</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0109702 INIST</idno><idno type="RBID">Pascal:12-0109702</idno><idno type="wicri:Area/PascalFrancis/Corpus">000222</idno><idno type="wicri:Area/PascalFrancis/Curation">000A30</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000191</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000191</idno><idno type="wicri:doubleKey">0039-128X:2012:Ismaili J:brassinosteroids:and:analogs</idno><idno type="wicri:Area/Main/Merge">001605</idno><idno type="wicri:Area/Main/Curation">001548</idno><idno type="wicri:Area/Main/Exploration">001548</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Brassinosteroids and analogs as neuroprotectors: Synthesis and structure-activity relationships</title><author><name sortKey="Ismaili, Jihane" sort="Ismaili, Jihane" uniqKey="Ismaili J" first="Jihane" last="Ismaili">Jihane Ismaili</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Boisvert, Martin" sort="Boisvert, Martin" uniqKey="Boisvert M" first="Martin" last="Boisvert">Martin Boisvert</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Longpre, Fanny" sort="Longpre, Fanny" uniqKey="Longpre F" first="Fanny" last="Longpre">Fanny Longpre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Le Gall, Celine" sort="Le Gall, Celine" uniqKey="Le Gall C" first="Céline" last="Le Gall">Céline Le Gall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author><author><name sortKey="Daoust, Benoit" sort="Daoust, Benoit" uniqKey="Daoust B" first="Benoit" last="Daoust">Benoit Daoust</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Département de Chimie-Biologie, Groupe de Recherche en Neuroscience, Université du Quebec à Trois-Rivières, 3351 Boulevard des Forges, C.P. 500, Trois-Rivières</s1><s2>Québec G9A 5H7</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec G9A 5H7</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Steroids</title><title level="j" type="abbreviated">Steroids</title><idno type="ISSN">0039-128X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Steroids</title><title level="j" type="abbreviated">Steroids</title><idno type="ISSN">0039-128X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analog</term><term>Biosynthesis</term><term>Neuroprotection</term><term>Parkinson disease</term><term>Structure activity relation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Analogue</term><term>Biosynthèse</term><term>Relation structure activité</term><term>Neuroprotection</term><term>Maladie de Parkinson</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have demonstrated previously that the brassinosteroid (BR) 24-epibrassinolide exerts neuroprotective effects deriving from its antioxidative properties. In this study, we synthesized 2 natural BRs and 5 synthetic analogs and analyzed their neuroprotective actions in neuronal PC12 cells, against 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>), a neurotoxin known to induce oxidative stress and degenerescence of dopaminergic neurons characteristic of Parkinsonian brains. We also tested the neuroprotective potential of 2 commercially available BRs. Our results disclosed that 6 of the 9 BRs and analogs tested protected neuronal PC12 cells against MPP<sup>+</sup> toxicity. In addition, our structure-activity study suggests that the steroid B-ring and lateral chain play an important role for their neuroprotective action.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Ismaili, Jihane" sort="Ismaili, Jihane" uniqKey="Ismaili J" first="Jihane" last="Ismaili">Jihane Ismaili</name></noRegion><name sortKey="Boisvert, Martin" sort="Boisvert, Martin" uniqKey="Boisvert M" first="Martin" last="Boisvert">Martin Boisvert</name><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name><name sortKey="Daoust, Benoit" sort="Daoust, Benoit" uniqKey="Daoust B" first="Benoit" last="Daoust">Benoit Daoust</name><name sortKey="Le Gall, Celine" sort="Le Gall, Celine" uniqKey="Le Gall C" first="Céline" last="Le Gall">Céline Le Gall</name><name sortKey="Longpre, Fanny" sort="Longpre, Fanny" uniqKey="Longpre F" first="Fanny" last="Longpre">Fanny Longpre</name><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001548 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001548 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0109702
|texte= Brassinosteroids and analogs as neuroprotectors: Synthesis and structure-activity relationships
}}
| This area was generated with Dilib version V0.6.29. |  |